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Center for Research on Ingredient Safety

CRIS Funded Proposals

Congratulations to the recipients of our Fall 2016 CRIS RFP!

Congratulation to MSU professors Sarah Comstock (Assistant Professor, Food Science & Human Nutrition), Sudin Bhattacharya (Assistant Professor, Institute for Integrative Toxicology), and Adam Moeser (Associate Professor, Veterinary Medicine, Large Animal Clinical Sciences) for their proposal on Modeling the Interaction of Dietary Fibers, Gut Bacteria & Gastrointestinal Health.  We look forward to hearing of their progress on this project in the months to come.

Sarah ComstockSarah Comstock, Assistant Professor, Food Science and Human Nutrition

 

 

 

Sudin BhattacharyaSudin Bhattacharya, Assistant Professor, Biomedical Engineering, Pharmacology and Toxicology

 

 

Adam MoeserAdam Moeser, Associate Professor, Veterinary Medicine, Large Animal Clinical Sciences

 

 

 

Abstract: 
Dietary intake drives the formation of intestinal bacterial communities. These bacterial communities are pivotal for gastrointestinal health, likely acting through interactions with intestinal epithelial cells and the host immune system. At this point in time, there is no method by which to predict how specific dietary components interact with intestinal bacteria to modulate intestinal barrier function. The goal of our collaboration is to begin to develop a computational model which could be used to predict the effects of specific dietary components on intestinal microbial changes and subsequent gastrointestinal parameters. To address the effects of ingredients on microbiota, we will use samples from pigs that have been fed diets containing a variety of complex oligosaccharides (i.e. dietary fiber). By applying next-generation sequencing techniques to DNA and mRNA isolated from the intestinal mucosa of these pigs and using data previously gathered about the intestinal permeability, mucus thickness and other intestinal morphology data from these pigs, we will develop a computational model that relates dietary fiber intake to specific changes in intestinal barrier function. If successful, this computational model could be further refined and adjusted to be more broadly applicable to a number of dietary inputs. 

 

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Save The Date! The 2017 CRIS Annual Meeting will be held at ASU’s Phoenix campus on October 4 – 5, 2017. Please contact Adelle Simmons at asimmons@msu.edu for more details.