Welcome to CRIS
The Center for Research on Ingredient Safety at Michigan State University (CRIS) is one of the few organizations in the world willing to tacklethe hard questions about ingredient safety in our everyday products.

GRAS Loophole?
Recently, the Department of Health and Human Services leadership has suggested that the GRAS process needs to be changed. In this post, we provide context to help you better understand what…
Latest News

Community Request – Diacetyl
In this community request, we look at diacetyl, a compound that’s caused safety confusion.
Top Takeaways:
Diacetyl is safe for ingesting in food and beverages.
Some vape and e-cigarette liquids contain diacetyl.
You should avoid inhaling diacetyl in all forms.
What is diacetyl?
Diacetyl…

In the news – Toxic cookies?
We’ve seen concerns about the safety of Girl Scouts cookies making the rounds in the news. In this post, we explore the claims around toxic cookies.

Preservative tBHQ
New research in part funded by CRIS, now live in Frontiers Immunology, discusses the preservative ingredient tBHQ. In this post, we look at tBHQ and its impact on immune systems.
Current Research

Preservative tBHQ
New research in part funded by CRIS, now live in Frontiers Immunology, discusses the preservative ingredient tBHQ. In this post, we look at tBHQ and its impact on immune systems.

Working Group: Identification and Validation of Cell-based Assays for Developmental Immunotoxicity Testing
Overview:
It is increasingly clear that the global rise in inflammatory diseases and immune-mediated disorders can be traced back to early development.
The International Working Group on Alternatives to in vivo Developmental Immunotoxicity (DIT) Testing is working to identify and validate new models…