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Research

We, at the Center for Research on Ingredient Safety at Michigan State University (CRIS), add rigor and meaningful data to the current scholarly knowledge around ingredients by serving as a hub for objective, evidence-based research. We do this by

  • expanding the opportunity to conduct basic and applied research on the safety and toxicology of ingredients in food, packaging, cosmetics, and household care products.
  • contributing to the development and validation of testing methods and strategies for evaluating the safety of ingredients in food, packaging, cosmetics, and household care products.

We care deeply about protecting the integrity of all research conducted by CRIS. That is why our research is conducted under the direction of academic scientists who specialize in toxicology, immunology, microbiology, physiology, and other related sub-fields.

These accomplished researchers conduct the science by using standardized and recognized scientific methods to provide unbiased, researcher-derived conclusions. These conclusions are then sent for peer review at high-tier journals and, after acceptance into a peer-reviewed journal or scientific meeting, we inform the sponsors of the research, CRIS Partners and the greater community of the results, conclusions, and possible actionable outcomes.

Keeping our research processes transparent is imperative to maintaining integrity. Read more about out process here

Our Process

Latest Research

Working Group: Identification and Validation of Cell-based Assays for Developmental Immunotoxicity Testing

Overview: It is increasingly clear that the global rise in inflammatory diseases and immune-mediated disorders can be traced back to early development. The International Working Group on Alternatives to in vivo Developmental Immunotoxicity (DIT) Testing is working to identify and validate new models…
Read More - Link to more about Working Group: Identification and Validation of Cell-based Assays for Developmental Immunotoxicity Testing


Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroid

Abstract: The United States Food and Drug Administration recently approved the use of Cannabis sativa derived cannabidiol (CBD) in the treatment of Dravet Syndrome and Lennox-Gastaut Syndrome, under the trade name, Epidiolex. In double-blinded, placebo-controlled clinical trials, elevated ALT levels were observed…
Read the full study - Link to more about Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroid

The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice

Title: The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice Abstract: Objective -To test the effect of two dietary antioxidants: butylated hydroxytoluene (BHT) and 3- hydroxytyrosol (3-HT) in experimental food allergy. Methods - BALB/c mice maintained on control diet or diet…
Read the full study - Link to more about The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice