Cannabidiol (CBD)

cannabidiol

Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroid

Investigators: Jinpeng Li, Joe Zagorski, Norbert Kaminski
- Cannabidiol (CBD) Research
Abstract: The United States Food and Drug Administration recently approved the use of Cannabis sativa derived cannabidiol (CBD) in the treatment of Dravet Syndrome and Lennox-Gastaut Syndrome, under the trade name, Epidiolex. In double-blinded, placebo-controlled clinical trials, elevated ALT levels were observed…
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cannabidiol

Cannabidiol selectively modulates interleukin (IL)-1β and IL-6 production in toll-like receptor activated human peripheral blood monocytes

Investigators: Sera Sermet, Jinpeng Li,, Anthony Bach,  Robert B Crawford, Norbert Kaminski 
- Cannabidiol (CBD) Research
Abstract: Cannabidiol (CBD) is a major non-euphoric cannabis-derived compound that has become popular in its over-the-counter use. CBD possesses low affinity for cannabinoid receptors, while the primary molecular target(s) by which it mediates biological activity remain poorly defined. Individuals commonly self-medicate using…
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cannabidiol

The current understanding of the benefits, safety, and regulation of cannabidiol in consumer products

Investigators: Jinpeng Li, Ricardo Carvajal, Leon Bruner, Norbert Kaminski
- Cannabidiol (CBD) Research
Abstract: The popularity of cannabidiol (CBD) in consumer products is soaring as consumers are using CBD for general health and well-being as well as to seek relief from ailments especially pain, inflammation, anxiety, depression, and sleep disorders. However, there are limited data…
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