Research

Working Group: Identification and Validation of Cell-based Assays for Developmental Immunotoxicity Testing

- Research
Overview: It is increasingly clear that the global rise in inflammatory diseases and immune-mediated disorders can be traced back to early development. The International Working Group on Alternatives to in vivo Developmental Immunotoxicity (DIT) Testing is working to identify and validate new models…
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cannabidiol

Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroid

Investigators: Jinpeng Li, Joe Zagorski, Norbert Kaminski
- Cannabidiol (CBD) Research
Abstract: The United States Food and Drug Administration recently approved the use of Cannabis sativa derived cannabidiol (CBD) in the treatment of Dravet Syndrome and Lennox-Gastaut Syndrome, under the trade name, Epidiolex. In double-blinded, placebo-controlled clinical trials, elevated ALT levels were observed…
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The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice

- Research Tert-butylhydroquinone (tBHQ)
Title: The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice Abstract: Objective -To test the effect of two dietary antioxidants: butylated hydroxytoluene (BHT) and 3- hydroxytyrosol (3-HT) in experimental food allergy. Methods - BALB/c mice maintained on control diet or diet…
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cannabidiol

Cannabidiol selectively modulates interleukin (IL)-1β and IL-6 production in toll-like receptor activated human peripheral blood monocytes

Investigators: Sera Sermet, Jinpeng Li,, Anthony Bach,  Robert B Crawford, Norbert Kaminski 
- Cannabidiol (CBD) Research
Abstract: Cannabidiol (CBD) is a major non-euphoric cannabis-derived compound that has become popular in its over-the-counter use. CBD possesses low affinity for cannabinoid receptors, while the primary molecular target(s) by which it mediates biological activity remain poorly defined. Individuals commonly self-medicate using…
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cannabidiol

The current understanding of the benefits, safety, and regulation of cannabidiol in consumer products

Investigators: Jinpeng Li, Ricardo Carvajal, Leon Bruner, Norbert Kaminski
- Cannabidiol (CBD) Research
Abstract: The popularity of cannabidiol (CBD) in consumer products is soaring as consumers are using CBD for general health and well-being as well as to seek relief from ailments especially pain, inflammation, anxiety, depression, and sleep disorders. However, there are limited data…
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Titanium Dioxide powder

Academic Journal Publication – Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2)

- Research Titanium Dioxide
Abstract:  The toxicity of dietary E 171, a food grade titanium dioxide was evaluated. A recent study reported rats receiving E 171 in water developed inflammation and aberrant crypt foci (ACF) in the gastrointestinal tract. Here, rats received food containing E 171…
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White candy in yellow vending machines

Study suggests French ban on food additive may be premature

Story By: Norbert Kaminski - Source: MSU Today
- Research Titanium Dioxide
Michigan State University and University of Nebraska Medical Center researchers are refuting an earlier French government-funded study that claims titanium dioxide, a common food additive used worldwide, causes digestive inflammation and lesions in rats.
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