We see collagen supplements and cosmetics regularly trend. In this post, we take a deeper look at collagen.
Updated: July 21, 2025
Top Takeaways:
- Collagen is a key structural protein made naturally by our bodies from amino acids.
- Eating a balanced diet is more important than taking supplements.
- Collagen supplements show limited evidence of efficacy.
- Medical-grade collagen is different than over-the-counter supplements.
What is collagen?
Collagen is a structural protein that works as a connective tissue, constructing, mechanizing, and binding our bones, tendons, ligaments, cartilage, muscles, blood vessels, corneas, and other parts of our bodies. We know of at least 28 types of collagen.
Our bodies make collagen using amino acids. We get the amino acids needed to produce collagen through a healthy, balanced diet.
Where do we find collagen?
Collagen is naturally produced in our bodies, and it is found in all animals, not just humans.
Omnivores can eat collagen-containing foods such as chicken or pig skin, bone broth, and more. While these foods may contain collagen, it doesn’t necessarily translate directly into our bodies producing more collagen. Our bodies digest food, extract the necessary nutrients from it, and eliminate what we do not need.
Our bodies will produce collagen when we have the correct nutrition. While collagen-rich foods can help support our health, they aren’t the only nutrients needed to support our collagen production.
Often, producers and researchers who use collagen get the material from porcine, bovine, equine, marine, or human sources depending on the use case.
How is collagen used?
Historically, we’ve used collagen from animals to make gelatin and glue. Today, we use collagen from animal sources in medical applications, over-the-counter and medical-grade cosmetic products, dietary supplements, gelatin, and more.
We’ve seen a recent uptick in the use of collagen in the beauty and wellness industries. Since our bodies naturally decrease collagen production as we age, manufacturers have developed collagen-containing products aimed at improving skin appearance, hair and nail appearance and growth, and joint health.
These products can be supplements taken in pill or powder form or lotions applied topically to the skin.
We see medical-grade cosmetic injections that contain collagen, usually from bovine sources, to plump, sculpt, and fill faces.
Collagen is also used in a variety of medical and surgical procedures.
Do I need collagen supplements? Do they work?
There isn’t robust evidence to support that ingesting collagen supplements is an effective way to improve your health or boost collagen production. That’s not to say that they are completely ineffective, as some research has shown positive results.
However, other research does not support the idea that ingesting collagen supplements dramatically improves one’s health or appearance, and some researchers question the quality and methodologies of these studies.
Remember, our bodies make collagen from amino acids. We obtain the amino acids necessary for collagen production through a healthy, balanced diet.
However, collagen used in medical settings, such as wound healing, surgical repairs, cosmetic surgery, and medical-grade cosmetic products, differs from taking an oral collagen supplement. Collagen designed for medical purposes has different properties, specific purities, and other qualities that are fundamentally different than an oral supplement.
Are collagen supplements safe?
Dietary supplements are not regulated as medications, so it’s essential to look for reputable companies that use an independent laboratory, such as NSF International, ConsumerLab, or the U.S. Pharmacopeia, to test for quality standards. Products certified by independent laboratories will usually include a label that lets us know the manufacturer had the product tested to meet the laboratory’s certification standard.
Collagen supplements are not necessarily harmful. However, they can contain excessive amounts of protein. Too much protein can harm kidney health.
It’s essential to consult your board-certified and state-licensed medical professional or pharmacist before taking any supplement, including collagen.
The good news.
Researchers are continually uncovering innovative ways to use collagen to advance human health, from tendon and organ repair to wound healing and other cutting-edge medical applications. Most importantly, collagen is already a natural and essential part of our bodies, and with the right nutrients and support, our bodies know exactly how to make it without the need for specific supplements.
If you have any questions about ingredients or ideas for a blog post, please send us an email or submit your idea to us at go.msu.edu/cris-idea.
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bou Neel, E. A., Bozec, L., Knowles, J. C., Syed, O., Mudera, V., Day, R., & Hyun, J. K. (2013). Collagen—emerging collagen-based therapies hit the patient. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2012.08.010
Anderson, E. Li, J., Exploring regulations. (2024).MSU Center for Research on Ingredient Safety. Retrieved from https://cris.msu.edu/news/dietary-supplements/exploring-regulations/
Anderson, E. Li, J., Everyday toxicology: Absorbing, processing, eliminating ingredients. (2020). MSU Center for Research onIngredient Safety. Retrieved from https://cris.msu.edu/news/everyday-toxicology/everyday-toxicology-absorbing-processing-eliminating-ingredients/
Bolke, L., Schlippe, G., Gerß, J., & Voss, W. (2019). A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, andDensity: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients, 11(10),2494. https://doi.org/10.3390/nu11102494
Collins, C., Thinking about trying collagen supplements for your skin? A healthy diet is better value for money. (2021, November12). The Conversation. Retrieved from https://theconversation.com/thinking-about-trying-collagen-supplements-for-your-skin-a-healthy-diet-is-better-value-for-money-152240
Injectable polymethylmethacrylate & bovine collagen filler. American Society for Dermatologic Surgery. Retrieved from https://www.asds.net/skin-experts/skin-treatments/injectables/injectable-polymethylmethacrylate-bovine-collagen-filler
Jhawar, N., Wang, J. V., & Saedi, N. (2020). Oral collagen supplementation for skin aging: A fad or the future?. Journal of cosmetic dermatology, 19(4), 910–912. https://doi.org/10.1111/jocd.13096
Lee, C. H., Singla, A., & Lee, Y. (2020). Biomedical applications of collagen. International Journal of Pharmaceutics. https://doi.org/10.1016/S0378-5173(01)00691-3
Myung, S. K., & Park, Y. (2025). Effects of CollagenSupplements on Skin Aging: A Systematic Review and Meta-Analysis of RandomizedControlled Trials. The American journal of medicine,S0002-9343(25)00283-9. Advance online publication. https://doi.org/10.1016/j.amjmed.2025.04.034
Ricard-Blum S. (2011). The collagen family. ColdSpring Harbor perspectives in biology, 3(1), a004978. https://doi.org/10.1101/cshperspect.a004978
Sionkowska, A., Adamiak, K., Musiał, K., & Gadomska,M. (2020). Collagen Based Materials in Cosmetic Applications: A Review. Materials, 13(19), 4217. https://doi.org/10.3390/ma13194217